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WADA Announces CPT Update for Monkeypox Testing and Vaccination

July 27, 2022 – The American Medical Association (AMA) today announced an update to Current Procedural Terminology (CPT)®the nation’s primary set of medical terminology codes for describing health care procedures and services, which includes a new laboratory test code for orthopoxvirus and two codes for vaccines used to prevent monkeypox infection .

These new CPT codes are effective for immediate use and are designed to clinically distinguish monkeypox diagnostic testing and vaccinations to support the data-based monitoring, reporting and analysis needed for planning and resource allocation during the public health response to the outbreak.

“Following the declaration by the World Health Organization (WHO) of monkeypox a global health emergency, and with the increase in the number of cases in the United States, these updates from the CPT are timely. “said WADA President Jack Resneck Jr., MD. US cases show ongoing community spread; However, we are relieved to see that access to testing has increased to 80,000 samples per week with commercial labs now online and vaccine supplies are increasing. Monkeypox is most often spread from person to person through close personal contact, but preventive measures can help you avoid infection. We urge patients to consult reputable, evidence-based sources like the CDC and AMA and to contact their doctor if they have any questions about the prevention, diagnosis, or treatment of monkeypox.

The new lab test code CPT (87593) describes a molecular diagnostic test that detects the nucleic signature of an orthopoxvirus, including Monkeypox virus.

The two new vaccine codes are designed to describe the two pox and monkeypox virus products currently available. The first code (90622) describes the existing FDA-approved ACAM2000 vaccine manufactured by Sanofi Pastuer Biologics Co. for active immunization against smallpox in persons considered to be at high risk of smallpox infection. The second code (90611) describes the FDA-approved JYNNEOS vaccine manufactured by Bavarian Nordic for the prevention of smallpox and monkeypox in adults 18 years and older at high risk of smallpox or smallpox infection of the monkey.

The short, medium and long descriptors of the new CPT codes can be accessed on the WADA website, but for quick reference, the new CPT update includes the following codes and descriptors:

Lab test code

87593 Detection of infectious agents by nucleic acid (DNA or RNA); orthopoxvirus (eg, monkeypox virus, cowpox virus, vaccinia virus), amplified probe technique, each

Product code

90622 Vaccinia virus (smallpox) vaccine, live, freeze-dried, 0.3 mL strength, for percutaneous use

90611 Smallpox and monkeypox vaccine, attenuated vaccinia virus, live, non-replicating, preservative-free, 0.5 mL strength, suspension, for subcutaneous use

Changes to the CPT code set are reviewed through an open editorial process managed by the CPT Editorial Board which garners extensive input from the healthcare community and beyond to ensure CPT content reflects requirements of coding digital health, precision medicine, augmented intelligence and other aspects of a modern healthcare system. This rigorous editorial process keeps the CPT code set up to date with contemporary medical science and technology so that it can fulfill its vital role as the trusted language of medicine today and the code for its future.

Questions about CPT coding and content should be directed to the CPT network, the authoritative source for CPT coding answers. See also the AMA online library of COVID-19 CPT Coding and Guidance.

About the American Medical Association
The American Medical Association is the physician’s powerful ally in patient care. As the only medical association that unites more than 190 state and specialty medical societies and other critical stakeholders, the AMA represents physicians with a unified voice to all key healthcare stakeholders. The AMA leverages its strength by breaking down barriers that interfere with patient care, leading the charge to prevent chronic disease and address public health crises, and leading the future of medicine to meet the challenges. greatest health care challenges. For more information, visit

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